Worldâ€™s Largest Nuclear Explosion The Tsar Bomb was the largest nuclear weapon ever constructed or detonated. It was detonated at 4000 m altitude the 30th of October 1961 at Mityushikha Bay test range, Novaya Zemlya Island. It had a yield of 50 Megatons. Link This entry was posted in Uncategorized. Bookmark the permalink.